Unofficial Side Effects of CGRP Monoclonal Antibodies

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Key Questions
  • What are calcitonin gene-related peptide (CGRP) inhibitors and how do they work?
  • What is the “mechanism of action” in CGRP inhibitors?
  • What CGRP-inhibitor medications are currently available?
  • What are CGRP monoclonal antibodies (mAbs)?
  • What are the most common side effects of CGRP inhibitors reported in clinical trials?
  • What side effects of these medications are commonly seen in practical use?
  • How do side effects differ from adverse events?
  • Are weight gain, hair loss, and GI issues common side effects of all CGRP mAbs?
  • Can CGRP mAbs affect mood and anxiety levels?
  • Can CGRP mAbs affect bone density?
  • Does CGRP play a role in our immune system?
  • Are there any known risks or side effects when combining CGRP inhibitors with other medications?
  • What should someone do if they are experiencing side effects from their medication?
Interview Notes
Treatments Mentioned
  • Atogepant (Qulipta)
  • CGRP inhibitors
  • CGRP monoclonal antibodies (mAbs)
  • CGRP small-molecule receptor antagonists (gepants)
  • Eptinezumab (Vypeti)
  • Erenumab (Aimovig)
  • Fremanezumab (Ajovy)
  • Galcanezumab (Emgality)
  • Laxatives
  • Topiramate (Topamax)
  • Triptans

Please note: The Migraine World Summit’s aim is to bring you a variety of perspectives and expertise, independent of bias or judgment. Alternative theories presented in this video have not been medically reviewed. Views expressed in this interview do not necessarily represent the views of the Migraine World Summit. Please always consult your health care professional and do your own research before making changes to your treatment plan.

Robert P. Cowan, MD

Professor of Neurology & Director of Research in Headache and Facial Pain
Stanford University School of Medicine

Dr. Robert P. Cowan is a clinical professor of neurology and director of the Stanford Headache and Facial Pain Program Research division at Stanford University. He is board certified in neurology and pain medicine with a subspecialty certification in headache medicine. Dr. Cowan has held several nationally elected positions, including chair of multiple sections for the American Headache Society (AHS).

He is the past president of the Headache Cooperative of the Pacific and was the founding chief of the headache division in the Department of Neurology at Stanford, and before that, at the Keck School of Medicine of USC. He is a fellow of the American Academy of Neurology and the American Headache Society. He has served on the boards of the Alliance for Headache Disorders Advocacy and the now-defunct American Headache and Migraine Association. He has published over 200 articles, chapters, abstracts, and posters and is the author of The Keeler Migraine Method.

Interviews from Robert P. Cowan, MD

Unofficial Side Effects of CGRP Monoclonal Antibodies
Long-Term Effects of New Migraine Medications
Why Most Doctors Get the Diagnosis Wrong
Best Natural, Affordable and Free Treatments
Migraine Causes & Triggers

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