Psychedelics for the Treatment of Headache Disorders

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Key Questions
  • What are psychedelics?
  • What is microdosing?
  • What is psilocybin, also referred to as “magic mushrooms”?
  • What conditions have been found to respond to psychedelic treatment?
  • What has research revealed about psychedelics in preventing migraine?
  • How do psychedelics compare to pharmaceuticals in treating migraine?
  • What is ketamine?
  • Can psychedelics help treat veterans with post-traumatic headache?
  • Are there any risks associated with the use of psychedelics?
  • How do psychedelics compare to CBD and cannabis, as well as nutritional supplements like feverfew and butterbur, for treating migraine?
Interview Notes
Treatments Mentioned
  • Butterbur
  • Cannabis
  • CBD
  • Feverfew
  • Ketamine
  • LSD (lysergic acid diethylamide)
  • Mescaline
  • Peyote
  • Psilocybin
  • Psychedelics

Please note: The Migraine World Summit’s aim is to bring you a variety of perspectives and expertise, independent of bias or judgment. Alternative theories presented in this video have not been medically reviewed. Views expressed in this interview do not necessarily represent the views of the Migraine World Summit. Please always consult your health care professional and do your own research before making changes to your treatment plan.

Emmanuelle Schindler, MD, PhD

Assistant Professor of Neurology
Yale School of Medicine

Dr. Schindler is a board-certified neurologist and headache medicine specialist at Yale School of Medicine in New Haven, Connecticut, and the medical director of the Headache Center of Excellence for the VA Connecticut Healthcare System. Among her efforts to optimize the management of headache disorders, she developed and executed the first studies seeking to understand the effects and mechanisms of action of psilocybin in cluster, migraine, and post-traumatic headache.

Previously, she studied the neuropharmacology of psychedelics and other serotonergic compounds in the context of receptor binding and intracellular signaling at Drexel University College of Medicine. She has published and presented on the biochemical, behavioral, neuropharmacological, neuroendocrinological, and therapeutic effects of psychedelics. Dr. Schindler remains at the forefront of headache medicine, and has won several awards for academic excellence. She has authored a number of publications and book chapters.

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