Migraine Genetics, MTHFR and Concussion

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Key Questions
  • What are some recent advances in the field of genetics and migraine?
  • Does migraine have a genetic basis?
  • What is a causative mutation, and how can it cause hemiplegic migraine?
  • Can people have a number of different gene mutations that are associated with migraine but still not have migraine?
  • What is the difference between inherited and acquired mutations?
  • Does our DNA determine the frequency or severity of our migraine?
  • Do we know the role that glutamate plays in migraine?
  • What are ions and ion channels?
  • What are MTHFR gene mutations and how do they affect migraine?
  • What can genetics tell us about concussion severity?
Interview Notes
Lyn Griffiths

Lyn Griffiths, PhD

Executive Director
Institute of Health and Biomedical Innovation

Professor Lyn Griffiths is the executive director of the Institute of Health and Biomedical Innovation, the largest interdisciplinary research institute at Queensland University of Technology. An active and respected molecular geneticist with more than 28 years of experience studying human complex gene disorders with specific expertise in the human gene mapping and gene expression analysis in migraine, cardiovascular disease and several types of cancer. Professor Griffiths leads the Genomics Research Centre in which the main focus of research is the identification of genes involved in common human disorders and the translation of this research into new diagnostics and therapeutics.

Professor Griffiths’ own genetics research has appeared in more than 350 peer-reviewed international journals and led to diagnostic breakthroughs for several neurogenetic disorders, including familial migraine, ataxia, epilepsy and hereditary stroke. A fellow of the Queensland Academy of Arts and Science, Professor Griffiths has also established several significant international collaborations with the Texas Biomedical Research Institute, Oxford University, University of Vienna, the Italian National Research Council, the MS ANZ Gene Consortium and the International Migraine Genetics Consortium.

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The American Migraine Foundation (AMF) is a non-profit organization dedicated to the advancement of research and awareness surrounding migraine, a disabling condition that impacts more than 37 million men, women and children in the United States. The AMF was founded in 2010 to provide global access to information and resources for individuals with migraine as well as their family and friends.

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