Migraine Prevention Compared: What Recent Research Shows

Day 4 (2026)

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Key Questions

What was the TEMPLE trial that compared topiramate and atogepant?
Why are so many individuals with migraine not currently taking a preventive medication?
Why is it important to consider treatment tolerability when it comes to preventive medications?
According to the TEMPLE study results, which preventive treatment was better tolerated by people with migraine, and why?
What is the primary difference between tolerable and intolerable side effects, and what are some examples of each?
What is meant by the phrase “50% responder rate” in clinical trials, and how well did atogepant and topiramate perform in relation to that responder rate?
What do the results of the TEMPLE study suggest overall about the treatment differences and efficacy between atogepant and topiramate?
Why are preventives such an important part of treatment for many individuals with migraine?
How should individuals decide when to continue with a preventive treatment if they are experiencing side effects from it?
When should individuals consider revisiting a long-standing migraine treatment plan with their doctors?

Interview Notes

Treatments Mentioned

Atogepant (Qulipta/Aquipta)
Topirimate (Topamax)

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Disclaimer: The Migraine World Summit aims to bring you a variety of perspectives and expertise, free from bias or judgment. Alternative theories presented in this video have not been medically reviewed. Views expressed in this interview do not necessarily represent the views of the Migraine World Summit. Please always consult your health care professional and do your own research before making changes to your treatment plan. Captions are auto-generated and may contain errors.

Expert

Jaclyn Duvall, MD

Founder and Director
Headache Specialists of Oklahoma

Dr. Jaclyn Duvall is a board-certified neurologist and UCNS-certified headache specialist based in Tulsa, Oklahoma. She is one of the state’s few fellowship-trained headache specialists and has provided neurologic care since 2013.

She completed her headache medicine fellowship at the Mayo Clinic, and her medical degree and neurology residency at the University of Oklahoma College of Medicine. Her clinical interests include chronic migraine, post-traumatic headache, and the doctor-patient relationship.

Dr. Duvall is actively involved in headache research, education, and advocacy, and is a member of the American Headache Society, American Academy of Neurology, International Headache Society, and the National Headache Foundation. She is a national and international speaker on headache medicine and has published research in leading journals including Headache, Neurology, and Cephalalgia. She is also the author of The Basics of Migraine.

Dr. Duvall is known for her patient-centered approach and her commitment to partnering with each individual to develop a personalized treatment plan.