What to Expect: Nurtec ODT, Ubrelvy, Qulipta & Zavzpret
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Key Questions
- What are CGRP small-molecule receptor antagonists (gepants)?
- How are gepants different from CGRP monoclonal antibodies?
- At what stage of a migraine attack should a gepant be taken?
- What gepants are currently available and how do they differ from each other?
- What are the doses and administration for each gepant?
- How does a doctor decide which gepant to try for each patient?
- How do gepants differ from triptans?
- What are some other options for patients who don’t respond to gepants?
- Are gepants effective for both episodic and chronic migraine?
- Can gepants be taken while pregnant or breastfeeding?
- Are there any drug interactions and/or risks associated with gepants?
- Can gepants be used to treat migraine in children or adolescents?
Interview Notes
- New York State Neurological Society
- American Headache Society
- Weill Cornell School of Medicine
- NewYork Presbyterian Hospital
- X (Twitter): @mrobbinsmd
- Press Release: “First-Of-Its-Kind Head-to-Head Clinical Trial Reaffirms the Efficacy of Emgality in Episodic Migraine Prevention”
- Study: “Comparing the efficacy and safety of galcanezumab versus rimegepant for prevention of episodic migraine: Results from a randomized, controlled clinical trial”
- MWS Interview: “Planning for Pregnancy With Migraine”
Treatments Mentioned
- Antibiotics
- Antifungal medications
- Celecoxib (Elyxyb)
- Atogepant (Qulipta)
- CGRP Inhibitors
- CGRP monoclonal antibodies (mAbs)
- CGRP small-molecule receptor antagonists (gepants)
- Diclofenac (Cambia)
- Dihydroergotamine (DHE and Trudhesa)
- Galcanezumab (Emgality)
- Lasmiditan (Reyvow)
- Neuromodulation devices
- Nirmatrelvir/ritonavir (Paxlovid)
- Rimegepant (Nurtec)
- Triptans
- Ubrogepant (Ubrelvy)
- Zavegepant (Zavzpret)
Please note: The Migraine World Summit’s aim is to bring you a variety of perspectives and expertise, independent of bias or judgment. Alternative theories presented in this video have not been medically reviewed. Views expressed in this interview do not necessarily represent the views of the Migraine World Summit. Please always consult your health care professional and do your own research before making changes to your treatment plan.
Matthew Robbins, MD
Associate Professor of Neurology and Residency Program Director
Weill Cornell Medicine, NewYork-Presbyterian Hospital
Matthew S. Robbins, M.D., is the program director for the neurology residency and an associate professor of neurology at Weill Cornell Medicine and NewYork-Presbyterian Hospital. His clinical practice focuses on patients with migraine, cluster headache, new daily persistent headache, other headache disorders, CSF (cerebrospinal fluid) leaks, and visual snow. He has experience with patient care, teaching, and research for headache disorder treatments, including monoclonal antibodies, procedures such as botulinum toxin injections and peripheral nerve blocks, and neuromodulation devices. Dr. Robbins developed an academic career integrating patient care, education and mentorship, research, and advocacy for people with headache and other neurological conditions.
Previously, Dr. Robbins earned his B.S. from Yale University and his M.D. from SUNY-Downstate College of Medicine. He completed his neurology residency at the Albert Einstein College of Medicine/Montefiore Medical Center, where he was also a chief resident and then a Fellow in Headache Medicine at the Montefiore Headache Center. He served on the faculty at Montefiore-Einstein for nearly a decade, where he was an associate professor of neurology, chief of neurology at the Jack D. Weiler Hospital, and director of inpatient services for the Montefiore Headache Center.
He serves as president-elect of the NewYork Neurological Society and on the board of directors of the American Headache Society. In addition, he is passionate about advocacy, and is a graduate of the Palatucci Advocacy Leadership Forum of the American Academy of Neurology.
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The Coalition For Headache And Migraine Patients (CHAMP) is an organization that provides support to people with headache, migraine and cluster diseases who are often stigmatized and under-served.
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