New Daily Persistent Headache: Pain That Won’t Stop

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Key Questions
  • What is new daily persistent headache (NDPH)?
  • Who is typically affected by NDPH?
  • Besides head pain, what symptoms are associated with NDPH?
  • What do we know about the triggers for continuous headache?
  • How does NDPH differ from chronic tension headache?
  • What options are available to treat NDPH?
  • Do treatments become less effective over time?
  • Are lifestyle and other nonpharmacological approaches helpful in treating persistent headache conditions?
  • What advice would you give to someone who feels like they have tried everything to manage their headache disorder?
  • Are there success stories about patients who have brought NDPH under control?
Interview Notes
Treatments Mentioned
  • Anti-seizure medicines
  • CGRP monoclonal antibodies (mAbs)
  • Cognitive behavioral therapy (CBT)
  • Exercise
  • Healthy eating
  • Hydration
  • Neuromodulation
  • Pain modulation devices
  • Regular sleep
  • TENS devices
  • Tricyclic antidepressants
  • Vagus (vagal) nerve stimulation

Please note: The Migraine World Summit’s aim is to bring you a variety of perspectives and expertise, independent of bias or judgment. Alternative theories presented in this video have not been medically reviewed. Views expressed in this interview do not necessarily represent the views of the Migraine World Summit. Please always consult your health care professional and do your own research before making changes to your treatment plan.

Andrew D. Hershey, MD, PhD, FAAN, FAHS

Endowed Chair & Director of Neurology; Professor of Pediatrics & Neurology
Cincinnati Children's Hospital Medical Center; University of Cincinnati College of Medicine

Dr. Hershey is a board-certified neurologist and the endowed chair and director of neurology at Cincinnati Children’s Hospital Medical Center. He also is a professor of pediatrics and neurology at the University of Cincinnati College of Medicine. Dr. Hershey’s research interests currently include the improved diagnosis and treatment of childhood headache disorders, characterization of outcome responses, studies in new pharmacological and nonpharmacological treatment regimes, and the genomics of migraines.

Dr. Hershey has been an active member of the International Headache Society since 1998, serving on several committees, including the Child and Adolescent Standing Committee (currently the chair of the committee), the Classification Committee, and most recently, the Grading Committee. He is also active in the American Headache Society (AHS), where he served as a board member from 2006-2016, as well as on several sections, and is currently the chair of the Guidelines Committee. For the American Academy of Neurology (AAN), he served two terms as the chair of the Headache and Facial Pain Section and was involved with writing the acute and preventive treatment guidelines for children and adolescents with migraine, co-sponsored by the AAN and the AHS. He has actively advised on many pharmaceutical studies and is an active member of several committees for the National Institutes of Health, including study groups under the HEAL (Helping to End Addiction Long-Term) Initiative.

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