Safety Update: DHE, Triptans, Magnesium, Butterbur & More

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Key Questions
  • What is the latest research on the cardiovascular safety of DHE (dihydroergotamine)?
  • Why are triptans — one of the top three acute migraine treatments — underutilized?
  • What safety concerns impede the use of triptans?
  • Why was rofecoxib (Vioxx) pulled from the market? Are there safety concerns for other selective COX-2 inhibitors in migraine management?
  • Is magnesium recommended for everyone?
  • Is magnesium intake through diet sufficient?
  • Are there safety concerns with magnesium supplementation?
  • What does the latest research say about the safety of butterbur?
  • Can daily use of preventive natural supplements (like feverfew and butterbur) cause dependence or medication overuse headache (MOH)?
Interview Notes
Treatments Mentioned
  • Acetaminophen (paracetamol)
  • Aspirin
  • Boswellia
  • Butterbur (Petadolex)
  • Celecoxib (Celebrex)
  • Codeine
  • Dihydroergotamine (DHE)
  • Excedrin
  • Feverfew
  • Fluoxetine (Prozac)
  • Ibuprofen
  • Magnesium
  • NSAIDs
  • OnabotulinumtoxinA (Botox)
  • Opioids
  • Percocet
  • Rofecoxib (Vioxx)
  • SSRIs
  • Sertraline (Zoloft)
  • Sumatriptan (Imitrex)
  • Triptans
  • Yoga

Please note: The Migraine World Summit’s aim is to bring you a variety of perspectives and expertise, independent of bias or judgment. Alternative theories presented in this video have not been medically reviewed. Views expressed in this interview do not necessarily represent the views of the Migraine World Summit. Please always consult your health care professional and do your own research before making changes to your treatment plan.

Alexander Mauskop, MD

New York Headache Center

Dr. Alexander Mauskop is the director and founder of the New York Headache Center. He is board certified in neurology, with subspecialty certification in headache medicine. Dr. Mauskop is a Fellow of the American Academy of Neurology and the American Headache Society. He is a professor of clinical neurology at SUNY Downstate Health Sciences University. He has published over a hundred articles, abstracts, and reviews, as well as four books. He has delivered more than 500 presentations and lectures in the field of headache over the past 30 years.

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