How Migraine & Chronic Fatigue Syndrome (ME/CFS) Are Connected

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Key Questions
  • What is myalgic encephalomyelitis or chronic fatigue syndrome (ME/CFS)?
  • Does ME/CFS involve more than just experiencing extreme fatigue?
  • How is ME/CFS diagnosed?
  • What is post-exertional malaise (PEM)?
  • What is the correlation between postural orthostatic tachycardia syndrome (POTS) and ME/CFS?
  • Could ME/CFS be underdiagnosed?
  • What causes ME/CFS?
  • Is there a genetic basis for ME/CFS?
  • Do hormones contribute to ME/CFS?
  • What is hyperalgesia?
  • What is the correlation between ME/CFS and migraine?
  • What are the treatment options for ME/CFS?
  • How can patients manage pain effectively and avoid medication overuse headache (MOH)?
  • Are there lifestyle changes or preventive measures that can help with ME/CFS and migraine?
  • How can patients advocate for themselves and educate their doctors about their conditions?
  • How can patients participate in research studies for ME/CFS and migraine?
Interview Notes
Treatments Mentioned
  • Activity pacing
  • Anti-inflammatory diet
  • Antioxidants
  • Biofeedback
  • Brain retraining
  • Carnitine
  • CGRP monoclonal antibodies (mAbs)
  • Cognitive behavioral therapy (CBT)
  • Coenzyme Q10 (CoQ10)
  • Cyclobenzaprine (Flexeril)
  • Ergot alkaloids
  • Hydration
  • N-acetyl cysteine
  • Occupational therapy
  • Pregabalin
  • Psychotherapy
  • Rest
  • SSRIs
  • Topiramate (Topamax)
  • Tricyclic antidepressants

Please note: The Migraine World Summit’s aim is to bring you a variety of perspectives and expertise, independent of bias or judgment. Alternative theories presented in this video have not been medically reviewed. Views expressed in this interview do not necessarily represent the views of the Migraine World Summit. Please always consult your health care professional and do your own research before making changes to your treatment plan.

James Baraniuk, MD

Georgetown University

James Nicholas Baraniuk, MD, is an associate professor with tenure in the Department of Medicine at Georgetown University. He is also the director of the Chronic Pain and Fatigue Research Center, located within the Georgetown University Medical Center in Washington, D.C. The Chronic Pain and Fatigue Research Center does research on chronic fatigue syndrome, Gulf War Illness, and other pain conditions. The research focuses on the areas of functional magnetic resonance imaging (fMRI); biomarker discovery through proteomic, metabolomic, and transcriptomic assays in blood and cerebrospinal fluid; autonomic testing and heart rate variability; and statistical analyses using machine learning, hierarchical clustering, and other data-mining methods.

Interviews from James Baraniuk, MD

How Migraine & Chronic Fatigue Syndrome Are Connected

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