Genetics Research: Hope for a Future of Personalized Migraine Care
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Key Questions
- What do we know about the genetics of migraine?
- How many genes have been currently identified in regards to migraine? Can we anticipate the discovery of more genes related to migraine?
- Despite mapping the human genome, why haven’t we developed a cure for migraine?
- What distinguishes monogenic from polygenic diseases, and does migraine exhibit both types?
- What percentage of migraine is due to genetics?
- What don’t we know about the genetics of migraine?
- What are the latest discoveries in migraine genetics?
- What is epigenetics and how is it important in migraine?
- Do metabolite levels contribute to migraine disease? What about inflammation?
- What findings can we expect in the next 5-10 years?
Interview Notes
- Dale Nyholt, PhD
- Statistical and Genomic Epidemiology Laboratory (SGEL)
- Study: “Migraine genetics: Status and road forward”
- Study: “Genome-wide analysis of 102,084 migraine cases identifies 123 risk loci and subtype-specific risk alleles”
- Study: “New and sex-specific migraine susceptibility loci identified from a multiethnic genome-wide meta-analysis”
- Article: “Can We Predict Those at Higher Risk for Migraine?”
Treatments Mentioned
- Omega-3 fatty acids
Please note: The Migraine World Summit’s aim is to bring you a variety of perspectives and expertise, independent of bias or judgment. Alternative theories presented in this video have not been medically reviewed. Views expressed in this interview do not necessarily represent the views of the Migraine World Summit. Please always consult your health care professional and do your own research before making changes to your treatment plan.
Dale Nyholt, PhD
Professor of Biomedical Sciences
Queensland University of Technology, Australia
Dale Nyholt, PhD, is a human geneticist expert in the statistical analysis of common complex traits. Professor Nyholt is the head of the Statistical and Genomic Epidemiology Laboratory (SGEL), Institute of Health and Biomedical Innovation (IHBI), Queensland University of Technology (QUT). He is also a professor at the School of Biomedical Sciences, Faculty of Health, QUT. Professor Nyholt’s expertise spans statistical genetic and genomic analysis, epidemiology, bioinformatics, and biostatistics.
The SGEL studies the role of genetics in the development and mechanism of human traits, with particular emphasis on migraine. The lab’s specific goal is to identify genetic risk factors, understand their biological consequences, and detect common genetic links with other disorders, including depression, endometriosis, and epilepsy. The identification of such causal genetic factors and how they interact with environmental exposures will provide a deeper understanding of the etiology of migraine and our ability to prevent and treat attacks, as well as facilitate the discovery of novel pathways, and thus identify new targets for drug therapy. SGEL also develops novel statistical bioinformatics programs used by researchers worldwide.
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