Migraine Relief Through Gut Health: Science & Solutions
Key Questions
- What is the relationship between migraine and the gut?
- What happens in the gut during a migraine attack?
- What are the connections between the microbiome, autonomic dysfunction, and gut health?
- What are mast cells, and do they play a role in migraine disease?
- What is “leaky gut,” and how do we know if we have it?
- How helpful are gut-function tests in the diagnosis and treatment of migraine?
- How is the gut involved in the production of CGRP and serotonin?
- What GI conditions are most commonly associated with migraine disease?
- How can treating GI issues help to manage migraine?
- What are some interventions for gut health that can potentially improve migraine?
Interview Notes
- Wade Cooper, DO
- Immunoglobulins Blood Test
- GI360
- Study: “Characterization and preclinical evaluation of a protease activated receptor 2 (PAR2) monoclonal antibody as a preventive therapy for migraine”
- Study: “Making migraine easier to stomach: The role of the gut−brain−immune axis in headache disorders”
- Study: “A causal effects of gut microbiota in the development of migraine”
- Study: “Association of blast exposure in military breaching with intestinal permeability blood biomarkers associated with leaky gut”
Treatments Mentioned
- Amitriptyline
- CGRP-targeted medications (CGRP inhibitors)
- Fiber
- Dairy-free diet
- Gluten-free diet
- Nortriptyline
- Omega-3s
- Probiotics
- Sumatriptan
- Tricyclic antidepressants (TCAs)
Please note: The Migraine World Summit’s aim is to bring you a variety of perspectives and expertise, independent of bias or judgment. Alternative theories presented in this video have not been medically reviewed. Views expressed in this interview do not necessarily represent the views of the Migraine World Summit. Please always consult your health care professional and do your own research before making changes to your treatment plan.
Wade Cooper, DO
Headache Specialist
Memorial Healthcare Institute for Neuroscience
Wade Cooper is a headache specialist and faculty member of the Memorial Healthcare Institute for Neuroscience in Howell, Michigan. He completed a neurology residency at Michigan State University and a fellowship in headache medicine at the Michigan Head Pain and Neurological Institute. He previously served as the headache medicine fellowship director at the University of Michigan.
Dr. Cooper has a special interest in the relationship between inflammatory disorders and autonomic dysfunction in those with chronic pain and headache. He was drawn to the field of headache medicine by the vast unmet need for those affected by chronic headache and facial pain.
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Over the past 50 years, our mission at the National Headache Foundation has been to further awareness of headache and migraine as legitimate neurobiological diseases. Much has changed during this time. With aid from advanced technology and clinical innovation, there are more treatment options than ever before. However, we understand that these diseases are still largely misunderstood and that finding the right treatment options for you requires insight.
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